刘秀,男,汉族,中共党员,博士,研究员,博士生导师。甘肃省遗传学会秘书长,中国科协“海智计划”甘肃基地甘肃农业大学草食动物基因组与分子改良工作站负责人,甘肃农业大学“定西标准化舍饲养羊专家院”首席专家,甘肃省科技特派员、甘肃省科普专家、金城首席科普专家,新西兰林肯大学访问学者。
一、教育经历
(1)2012/09-2015/06,甘肃农业大学,动物遗传育种与繁殖专业,博士
(2)2006/09-2009/06,甘肃农业大学,动物遗传育种与繁殖专业,硕士
(3)2002/09-2006/06,甘肃农业大学,生物技术(动物方向)专业,学士
二、科研与学术工作经历
(1)2023/12-至今, 甘肃农业大学,动物科学技术学院,研究员
(2)2016/12-2023/11,甘肃农业大学,动物科学技术学院,副研究员
(3)2019/02-2020/02,新西兰林肯大学,访问学者
(4)2012/12-2016/11,甘肃农业大学,研究测试中心,助理研究员
(5)2009/07-2012/11,甘肃农业大学,研究测试中心,研究实习员
三、研究方向
动物分子育种及适应性进化;宿主与肠道微生物互作机制。
四、教育教学
本科生:讲授《动物育种学》课程;
研究生:讲授《绵山羊选育理论与实践》和《草食动物生产体系和可持续发展》课程。
五、社会兼职
甘肃省遗传学会秘书长,甘肃省科技特派员,甘肃省科普专家,金城首席科普专家。
六、代表性成果
1.发表论文
[1] sha yuzhu, liu xiu, li xiongxiong, wang zhengwen, shao pengyang, jiao ting, he yanyu, zhao shengguo. succession of rumen microbiota and metabolites across different reproductive periods in different sheep breeds and their impact on the growth and development of offspring lambs. microbiome, 2024,12(1): 172. (if=13.8)
[2] yuzhu sha, xiu liu*, yanyu he, zhao shengguo, hu jiang, jiqing wang, wenhao li, pengyang shao, fanxiong wang, xiaowei chen, wenxin yang and zhuanhui xie. multi-omics revealed rumen microbiota metabolism and host immune regulation in tibetan sheep of different ages. frontiers in microbiology, 2024, 15: 1339889.(if=4)
[3] fanxiong wang, yuzhu sha, xiu liu*, yanyu he, jiang hu, jiqing wang,shaobin li, pengyang shao, xiaowei chen, wenxing yang, qianlin cheng, mingao, wei huang. study of the interactions between muscle fatty acid composition, meat quality-related genes and the ileum microbiota in tibetan sheep at different ages. foods, 2024, 13:679.(if=4.7)
[4] pengyang shao, yuzhu sha, xiu liu*, yanyu he, fanxiong wang, jiang hu, jiqing wang, shaobin li, xiaowei chen, wenxin yang, qianling chen, min gao. supplementation with astragalus root powder promotes rumen microbiota density and metabolome interactions in lambs. animals, 2024, 14(5):788.(if=2.7)
[5] wenxin yang, yuzhu sha, xiaowei chen, xiu liu*, yanyu he, fanxiong wang, jixing wang, pengyang shao, qianling chen, min gao, wei huang. the effect of the interaction between rumen microbiota density vfas and hepatic gluconeogenesis on the high-altitude adaptability of tibetan sheep. international journal of molecular sciences.2024,25(12): 2767.(if=4.9)
[6] qianling chen, yuzhu sha, xiu liu*, yanyu he, xiaowei chen, wenxin yang, min gao, wei huang, jiqingwang, jianwen he, lei wang*,unique rumen micromorphology and microbiota-metabolite interactions: features and strategies for tibetan sheep adaptation to the plateau, frontiers in microbiology, 2024,15:1471732 .(if=4)
[7] xiu liu*, xinyu guo, yuzhu sha, yanyu he, pengyang shao, jiang hu, jiqing wang, shaobin li, zhiyun hao. based on the co-evolution of lncrnas-microbiota and metabolites in rumen epithelium to analyze the adaptation characteristics of tibetan sheep of nutrient stress in cold season. fermentation, 2023,9(10):892. (if=3.7)
[8] yuzhu sha, xiu liu*, xiaoning pu, yanyu he, jiqing wang, shengguo zhao, pengyang shao, fanxiong wang, zhuanhui xie, xiaowei chen, wenxin yang. characterizing the dynamics of the rumen microbiota, its metabolites, and blood metabolites across reproductive stages in small-tailed han sheep. microbiology spectrum, 2023, 11 (6): e0286723. (if=3.7)
[9] lv w, sha y, liu x*, he y, hu j, wang j, li s, guo x, shao p, zhao f, li, m. interaction between rumen epithelial mirnas-microbiota-metabolites in response to cold-season nutritional stress in tibetan sheep. international journal of molecular sciences, 2023,24(19):14489.(if=5.6)
[10] sha y, guo x, he y, li w, liu x*, zhao s, hu j, wang j, li s, zhao z. synergistic responses of tibetan sheep rumen microbiota, metabolites, and the host to the plateau environment. international journal of molecular sciences, 2023, 24(19), 14856.(if=5.6)
[11] sha y, he y, liu x*, shao p, wang f, xie z, li w, wang j, li s, zhao s, chen g.interactions of rumen microbiota, and metabolites with meat quality-related genes to regulate meat quality and flavor of tibetan sheep under nutrient stress in the cold season. journal of applied microbiology, 2023,134(8):lxad182.(if=4.0)
[12] pengyang shao, yuzhu sha, xiu liu*, yanyu he, xinyu guo, jiang hu, jiqing wang, shaobin li, caiye zhu, guoshun chen, wenhao li. astragalus additive in feed improved serum immune function, rumen fermentation and the microbiota structure of early-weaned lambs. journal of applied microbiology, 2023,134(11): lxad278.(if=4.0)
[13] xiu liu*, yuzhu sha, weibing lv, guizhong cao, xinyu guo, xiaoning pu, jiqing wang, shaobin li, jiang hu*, yuzhu luo. multi-omics reveals that the rumen transcriptome, microbiome and its metabolome co-regulate cold season adaptability of tibetan sheep. frontiers in microbiology, 2022, 13:859601.(if=6.064)
[14] yuzhu sha, yanyu he, xiu liu*, shengguo zhao, jiang hu, jiqing wang, shaobin li, wenhao li, bingang shi, zhiyun hao. rumen epithelial development and metabolism related genes regulate their micromorphology and vfas mediating plateau adaptability of different ages in tibetan sheep. international journal of molecular sciences, 2022, 23(24): 16078.(if=6.208)
[15] yuzhu sha, yue ren, shengguo zhao, yanyu he, xinyu guo, xiaoning pu, wenhao li, xiu liu*, jiqing wang, shaobin li. response of ruminal microbiota–host gene interaction to high-altitude environments in tibetan sheep. international journal of molecular sciences, 2022, 23(20):12430. (if=6.208)
[16] guo x, sha y, lv w, pu x, liu x*, luo y, hu j, wang j, li s, zhao z. sex differences in rumen fermentation and microbiota of tibetan goat. microbial cell factories, 2022, 21(1): 55.(if=6.352)
[17] xinyu guo, yuzhu sha, xiaoning pu, ying xu, liangwei yao, xiu liu *, yanyu he, jiang hu, jiqing wang, shaobin li and guoshun chen*. coevolution of rumen epithelial circrnas with their microbiota and metabolites in response to cold-season nutritional stress in tibetan sheep. international journal of molecular sciences, 2022, 23(18): 10488. (if=6.208)
[18] liu xiu, zhou huitong, gong hua, liu wenting, fang qian, wang jiqing, li shaobin, hu jiang, hickford jonathan*. ovine toll-like receptor 9 (tlr9) gene variation and its association with flystrike susceptibility. animals, 2021,11(12): 3549.(if= 2.752)
[19] sha y, hu j, shi b, dingkao r, wang j, li s, zhang w, luo y, liu x*. supplementary feeding of cattle-yak in the cold season alters rumen microbes, volatile fatty acids, and expression of sglt1 in the rumen epithelium. peer j, 2021, 9:e11048.(if= 2.984)
[20] he y⁺, liu x⁺*, de j, kang s, munday j s*. altered hypoxia-induced and heat shock protein immunostaining in secondary hair follicles associated with changes in altitude and temperature in tibetan cashmere goats. animals, 2021, 11(10):2798.(if=2.752)
[21] lv weibing⁺, liu xiu⁺*, sha yuzhu, shi hao, wei hong, luo yuzhu, wang jiqing, li shaobin, hu jiang, guo xinyu, pu xiaoning. rumen fermentation-microbiota-host gene expression interactions to reveal the adaptability of tibetan sheep in different periods, animals, 2021, 11(12): 3529. (if= 2.752)
[22] liu x, sha y, dingkao r, zhang w, lv w, wei h, shi h,hu j, wang j, li s, hao z. interactions between rumen microbes, vfas, and host genes regulate nutrient absorption and epithelial barrier function during cold season nutritional stress in tibetan sheep. frontiers in microbiology, 2020, 11: 593062. (if=4.236)
[23] yuzhu sha, jiang hu, bingang shi, renqing dingkao, jiqing wang, shaobin li, wei zhang, xiu liu*. characteristics and functions of the rumen microbial community of cattle-yak at different ages. biomed research international, 2020, 3482692.(if=2.276)
[24] he y, munday js*, perrott m, wang g, liu x*, association of age with the expression of hypoxia-inducible factors hif-1alpha, hif-2alpha, hif-3alpha and vegf in lung and heart of tibetan sheep. animals, 2019, 9(9):673. (if=1.832)
[25] x liu, j hu, yz luo, jq wang, sb li and qm an, sequence diversity of the ola-dqa2 gene in the tibetan sheep, philipp agric scientist, 2014, 97(1):79-85.
[26] 刘秀,魏红,史浩,沙玉柱,王继卿,李少斌,吕卫兵,郭新羽,蒲小宁.草地放牧藏绵羊不同月份肉品质及脂肪酸特征分析,家畜生态学报,2024,45(5):35-43.
[27] 姚亮伟,沙玉柱,郭新羽,蒲小宁,徐英,王继卿,李少斌,郝志云,刘秀*,不同海拔藏绵羊肉品质、营养成分及肉质相关基因表达特征分析,中国农业科技导报,2024,26(3):66-75.
[28] 徐英,任越,沙玉柱,蒲小宁,郭新羽,姚亮伟,邵鹏阳,王继卿,李少斌,刘秀*,不同海拔藏绵羊肉质脂肪酸特征分析,中国农业科技导报,2024,26(4):67-76.
[29] 陈倩玲,沙玉柱,刘秀*,邵鹏阳,王翻兄,陈小伟,杨文鑫,谢转回,高敏,黄薇. 肠道微生物与线粒体互作调控动物脂肪沉积的研究进展,畜牧兽医学报,2024,55(6):2293-2303.
[30] 谢转回,沙玉柱,刘秀*,王翻兄,邵鹏阳,王继卿,李少斌,陈小伟,杨文鑫. 藏绵羊冷、暖季瘤胃微生物菌群代谢组特征分析,中国畜牧杂志,2024,60(07):169-182.
[31] 王翻兄,徐英,沙玉柱,邵鹏阳,谢转回,李文浩,王继卿,李少斌,陈小伟,杨文鑫,刘秀*.不同年龄藏绵羊肌肉脂肪酸特征分析,中国农业科技导报,2024,26(08): 74-83.
[32] 蒲小宁,沙玉柱,郭新羽,王继卿,胡江,李少斌,郝志云,石斌刚,徐英, 姚亮伟,刘秀*.小尾寒羊母羊不同繁殖阶段血液免疫指标、瘤胃发酵及微生物菌群特征,中国畜牧杂志,2023,59(09):177-183.
[33] 白晶晶,刘秀,藏绵羊低氧适应的血液生理指标特征研究. 青海畜牧兽医杂志, 2023,53(01): 19-22.
[34] 周建强,司思,祁增源,韩银仓,刘秀*,孙永刚*. 牦牛smad1基因第一外显子snps检测及与生长形状的关联分析.西北农业学报, 2023, 32(2):179-186.
[35] 郭新羽,沙玉柱,蒲小宁,吕卫兵,刘秀*,胡江,王继卿,李少斌,赵志东. 环境温度对动物肠道微生物菌群影响的研究进展.畜牧兽医学报, 2022, 53(09):2858-2866.
[36] 祁增源,高占红,周建强,韩银仓,刘秀*,孙永刚*. 青海高原型牦牛scd基因snp及单倍型与生长形状的关联性分析.农业生物技术学报,2022, 30(07): 1314-1320.
[37] 吕卫兵,牛彬,沙玉柱,魏红,史浩,胡江,王继卿,李少斌,刘秀*.放牧藏绵羊瘤胃热休克蛋白70家族基因表达特征及其与微生物的互作研究. 西北农业学报, 2022, 31(12):1535-1543.
[38] 史浩,沙玉柱,魏红,吕卫兵,文禹梁,刘秀*,王继卿,李少斌,胡江.藏绵羊暖、冷季瘤胃微生物菌群密度与其短链脂肪酸浓度互作分析.动物营养学报,2021, 33(3): 1-9.
[39] 魏红,沙玉柱,史浩,吕卫兵,王继卿,李少斌,胡 江,刘秀*.放牧藏绵羊暖、冷季瘤胃vfas与sglt1基因表达特征关联分析. 西北农业学报,2021,30(5):629-636.
[40] 沙玉柱,张伟,胡江,左志,石斌刚,赵志东,张成福,刘秀*.冷季补饲对那曲牦牛生长性能和血液生化指标的影响.中国牛业科学,2021, 47(03):30-33 96.
[41] 刘秀,张亚强,李少斌,王继卿,胡江,张伟. 藏绵羊egln1基因表达尧变异特征及其适应性分析.华北农学报,2019,34(01): 226-231.
[42] 何建文,张伟,刘秀*,李少斌,王继卿,胡江. 藏绵羊hmox1基因表达及其多态性与低氧适应性的关联分析.农业生物技术学报,2019,27(03): 441-448.
[43] 何建文,刘秀*,李少斌,王继卿,胡江.藏绵羊hmox2基因克隆、表达及其耐低氧适应性进化分析.农业生物技术学报,2018, 26(11): 1890-1899.
[44] 刘秀,胡江,王继卿,李少斌,李文浩,焦丹.藏绵羊dqa座位基因的适应性进化研究.农业生物技术学报,2016,24(07): 1039-1046.
[45] 刘秀,方素栎,王继卿,李少斌,杨勤,黄进强,成述儒,胡江,杨世海.甘南欧拉型藏绵羊屠宰性能分析.畜牧与兽医,2012,44(07): 46-49.
[46] 刘秀,胡江.藏绵羊基因ola-dqa2第2外显子多态性分析.中国农业科学,2009,42(08): 2930-2936.
2.授权专利
(1)刘秀,李少斌,王继卿,张亚强,王凤璋,与藏绵羊高原低氧适应性相关的遗传标记及其应用,发明专利,专利号:zl201711092589.2。
(2)刘秀,胡江,王继卿,李少斌,安清明,甘肃高山细毛羊生长速度相关基因leptin的pcr-sscp检测试剂盒及检测方法,发明专利,专利号:zl201410022438.x。
(3)刘秀,贺延玉,何建文,张伟,李少斌,王继卿,胡江,与藏绵羊高原低氧适应性相关的遗传标记及其应用,发明专利,专利号:zl201811382697.8
(4)刘秀,胡江,王继卿,李少斌,王凤璋,一种户外牛羊用饲料槽,实用新型专利,专利号:zl201721495603.9。
(5)刘秀,胡江,王继卿,李少斌,王凤璋,一种户外牛羊用饮水槽,实用新型专利,专利号:zl201721495031.4。
(6)刘秀,胡江,王继卿,李少斌,王凤璋,一种山羊窑洞养殖舍,实用新型专利,专利号:zl201721493974.3。
(7)刘秀,胡江,王继卿,李少斌,贺延玉,赵志东,张亚强,一种牛羊用营养舔砖支架,实用新型专利,专利号:zl201721905149.x。
(8)刘秀,李少斌,王继卿,胡江,一种绵羊防疫和药浴的设施,实用新型专利,专利号:zl201721905170.x。
(9)刘秀,张伟,胡江,李少斌,王继卿,一种羊用便携式自动收缩围栏,实用新型专利,专利号:zl201821516338.2。
(10)刘秀,张伟,胡江,王继卿,李少斌,一种节能、清洁型肉羊养殖舍,实用新型专利,专利号:zl201821516265.7。
3.成果奖励
(1)王继卿,刘秀,李少斌,谢文章,胡江,苟占发,陇东绒山羊优质高产新品群选育与产业化示范,甘肃省科技进步奖三等奖,2021年。
(2)胡江,李少斌,刘秀,王继卿,黄建伟,权金鹏,欧杰,闫晓波.优质肉牛产业提升关键技术研发与示范推广,甘肃省科技进步奖三等奖,2018年。
(3)杜晓华,刘秀,刘霞,马小军,胡江,王继卿,李少斌,安清明,李文浩,焦丹,藏绵羊腐蹄病及耐寒基因抗性相关基因检测技术集成与应用,甘肃省高校科技进步奖一等奖,2016年。
(4)马小军,刘秀,张小丽,王继卿,赵双全,李少斌,李娟娟,巴特尔,傲巴义尔,艾尼尔力图,幸福,王佳泰,罗秀刚,柴文琼,岳燕,河西绒山羊流产抗性相关基因分子标记技术研究,甘肃省高校科技进步奖一等奖,2014年。